Does fructose restore muscle glycogen?

Question
Why does fructose only replenish liver glycogen and not muscle glycogen?

Thanks!

Brent

Answer
Fructose can be transformed into glycogen in the skeletal muscle though at a slower rate than in liver and than glucose does.

This happens because of a slower absorption of fructose from the intestine and because the blood glucose level is higher after glucose intake than after fructose feeding -- leading to a higher plasma insulin level, which in in its own turn causes increased glucose uptake by tissues. Since fructose gives rise to more liver glycogen than glucose, it leaves less carbohydrates available for muscle glycogen resynthesis.

Tanya Zilberter

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